He began his activity as laboratory assistant at the Department of Bacteriology, the head of which was Victor Babes. In Paris he was laboratory assistant at the Department of Immunology. Human papillomavirus infections epidemiology pathogenesis and host immune response continued his studies of immunity with Ehrlich in Germany. On his return to France, Levaditi was admittedÂ to the Â«Pasteur InstituteÂ» by Metchnicoff, who guided him in his experiments in the field of phagocytosis.
Levaditi had significant contributions in virology, syphiligraphyÂ and chemotherapy. In heÂ demonstrated, in cooperation with Karl Landsteiner, the presence of the poliovirus in other tissues than in the nervous one, namely in the nasopharyngeal secretions, in the salivary glands and in the intestinal lymph nodes. InLevaditi isolated the poliovirus on a tissue explant, defined the histopathology of the experimental disease and demonstrated the ultrafiltrability of the poliovirus.
Already in he tried to applyÂ the chemoprophylaxis of the disease by intranasal route, a problem of actuality for the rhinoviruses. AfterLevaditi, assisted by Nicolau, elaborated at the Department of Bacteriology of the Faculty of Medicine in Cluj projects related to the study of other viruses: herpesviruses, vaccine virus and rabies virus group.
Â The investigations performed from rabies outlined an important chapter of the virological research on: the neurotropic ectodermoses.
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Levaditi introduced the term Â«neuroprobasiaÂ», which defines the progression of viruses along the nerve tracts. Levaditi in cooperation with P. Lepine coordonated two of the first treatises of virology: Â«Les ultravirus des maladies humainesÂ» Â«Ultraviruses of human diseasesÂ» and Â«Les ultravirus des maladies animalesÂ» Â«Ultraviruses of animal diseasesÂ» Levaditi had remarkable disciples in France Pierre Lepine, M.
Constantinescu, N. Stamatin, etc. Stefan S. Nicolau - Stefan Formation injection toxine botulique. Nicolau obtained in the M. Doctor of Medicine degree at the Faculty of Medicine in Cluj, where he began this collaboration with Levaditi. Passionate, meticulous and precise his research diaries are a model in this respect.
InLevaditi and Nicolau published a series of articles in which new properties of the viral agents are demonstrated: ultrafiltrability passage through the pores of a collodion membrane and the cell-mediated character of the antiviral immunity. In a broad prospective view of the pathogenesis of viral infections, Levaditi and Nicolau human papillomavirus infections epidemiology pathogenesis and host immune response, beside the viral cytocidal effect, the participation of the immune response of the host in the triggering of the symptomatology.
Nicolau also pioneered the concept of viral oncolysis in studies where the neurovaccinal virus was innolculated into grafted tumours. Ann Inst Pasteur37, Medical Hypotheses44, Tumours are more susceptible to viruses than normal cells and tumours act as "a sponge attracting viral replication".
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This hypothesis was rediscovered by Sinkovics and Horwath in and is now in the centre of interest for many biotechnology companies who enlarge cancer virotherapy models". With a remarkable intuition Nicolau promoted the concept human papillomavirus infections epidemiology pathogenesis and host immune response the oncogenic potential of the viral nucleic acids. The school of professor Nicolau provided significant arguments for the involvement of viruses in the general pathology. The Â«Stefan S.
Principles and Practice of Clinical Virology
NicolauÂ» Institute of Virology, which chronologically is one of the first institutions in this speciality in Euorpe, has celebrated in the 50th anniversary of its foundation. The Institute has ith origin in the nucleus of the Chair of Virology, which began its activity in in the framework of the Faculty of Medicine in Bucharest.
For the first time in the world, in the higher medical education, a separate discipline was devoted to the study of the ultrafiltrable infectious agenst. Afterwards, a team of inframicrobiology of the Academy was created, wich developedÂ into the actual Institute of Virology. Many disciples of the school founded by prof. Nicolau distinguished themselves by significant contributions: Adelina Derevic respiratory viral infectionsElisabeta Nastac virus-cancer relationshipsElena Oprescu respirtory viral infectionsRadu Portocala biochemistry of the viral nucleic acidsDan Sarateanu ornithoses tratament oxiuri copii, Constantin Surdan RickettsiaNicolae Cajal his succesor at the Institute and Chair of virology direction.
Implicarea genomului papiloma virusului uman (hpv) în oncogeneza cancerului cervical
From to he was Director of the Stefan S. Nicolau Institute of Virology. Disciple Â and collaborator of Professor Nicolau, N. Cajal published during his lifetime numerous reference studies regarding the persistent infections herpes, papillomatosis, measles ; the genetics of polioviruses and of other attenuated Â strains used in the prophylaxis of some viral diseases; the virus cancer relationships, as will as the relationships between the viral infections and the pathology of pregnancy and of the product of conception.
The scientific Â contribution of Professor Cajal is recorded in more than papers published in Romania and abroad. Inunder the editorship of Professor N.
Vaginal cancers and human papilloma virus
Cajal appeared the first volume of a remarkable treatise of Medical Virology. Cajal sustained and developed the concept of plurietiology of viral hepatitis. On the basis of an extensive clinical Â and pathomorphological study, the authors demonstrated the existence of several other viruses, with the exception of the recognized A and B types.
Later research on performed in various countries confirmed the conception and the priority of the Romanian authors. InProfessor Cajal initiated the antipoliomyelitic vaccination in Romania with the Sabin vaccine and followed-up the immunization level by antibody dosages.
Objects of Â concern for the elaboration andÂ improvement of vaccines werease the anti-influenza and anti-measles vaccines, and the effect of their administrtion by intranasal or intraconjunctival route was followed-up. Mutiu cell culturesA. Petrescu influenza ; V. Jucu viral persistence ; C. Cernescu his succesor at the Institute and chair of virology director. Dr Portocala was a founding member of the Institute with Stefan S.
Radu Portocala promoted molecular virology programs in the institute and authored the textbook Â«Â Les acides ribonucleiques cellulaires et virauxÂ Â» The cellular and viral ribonucleic acids Costin Eugen Cernescu Professor Costin Eugen Cernescu ascended all the steps of the didactic career and of the medical specialization from assistant and resident to senior physician and professor. He began this activity at the Institute of Virology of the Romanian Academy in as assistant at the Department of Inframicrobiology and as researcher and to works here also now, in the function of honorary director of human papillomavirus infections epidemiology pathogenesis and host immune response Institute.
At the Institute, Dr. Cernescu worked in a close collaboration with Academician Nicolae Cajal and published numerous studies regarding the persistent neuroinfections, the genetics of attenuated viruses used in the prophylaxis of some viral diseases, the antiviral immunnity.
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He published also several monographs, among which we mention: Schistosomiasis incubation period vaccinesÂ»Â«Measles etiopathogenesis and prophylaxisÂ»Â«Vaccines and vaccinationsÂ»Â«Pathogenesis of the chronic viral infectionÂ» Cernescu published significant studies regarding the emergence of the AIDS epidemic in the Constantza district; monitoring of its epidemiology by human papillomavirus infections epidemiology pathogenesis and host immune response of the case definition and of the disease staging; aspects of the AIDS encephalopaty in children; role of the macrophage in the pathogenesis of the HIV infection.
Cernescu was also interested in the study and the management of some viral epidemics which occurred during the last years in Romania, such as the study of the West-Nile meningoencephalitis, which acquired an epidemic form in Likewise, the study of the epidemiology of some parenterally transmitted viral diseases, such as the hepatitis B and C, and the study of sexually transmitted viral diseases and of eruptive viral diseases in children are fields of a permanent interest.
In his capacity of evaluator he has also participated in the national programmes applied under the aegs of the Romanian Academy, of the Ministry of Education and Research, of the Fogarty International Center and of the European Community FP 5 and 6.
In he was electid corresponding member of the Romanian Academy. He edited also a significant series of textbooks and monographs. We mention: Â«The textbook under the editorship of Acad. Mihai Stoian Already fromafter his graduation from the Faculty of Medicine in Bucharest, he opted, during his preclinical training as an intern, for the field of virology, which he did never abandon, not even now.
From onward, he undertook all steps of the academic career, obtaining the senior scientits chief researcher degree. During period he worked in the "Virus-tumor relationship" team, the coordinator of which he became after His scientific activity includes particularly interesting approaches to the viral study of some human neoplasia, of the bovine leucosis, of the genesis dynamics of antiviral antibodies in patients with neoplasia.
Other projectsÂ had as object the use of the viral oncolysis in the human medicine, theÂ immunotherapy in cancer, correlation between the hepatitis B virus and the hepatocellular carcinoma, involvement of the human papillomaviruses in the malignant pathology. He obtained in these fields, a series of significant results, which were published in Romania human papillomavirus infections epidemiology pathogenesis and host immune response abroad.
Mihai Stoian benefittedÂ by courses and training stages abroad, at outstanding speciality institutions: in a course of immunovirology in cancer Lyon human papillomavirus infections epidemiology pathogenesis and host immune response, in a Tempus scholarship at the Pasteur Institute Paris.
Dis Markers ; Mineral bone disorders MBDs constitute a hallmark of CKD, and alongside cardiovascular complications, they underlie a poor prognosis for these patients. Thus, our study focused on novel CKD biomarker patterns and their impact on the clinical staging of the disease. As a first testing approach, the relative expression levels of proteins were assessed by the Proteome Profiler Cytokine Array Kit for pooled CKD stage serum samples to establish an overall view regarding the proteins involved in CKD pathogenesis.
He published more than scientific articles. He obtained successively the professional degrees of specialist physician and senior physician in the specialities microbiology, virology and parasitology.
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He is doctor of medical sciences and coordinator the training for of the M. In collaboration with the group of Papilloma 6 11. Constantinescu contributed to the discovery of the JAK2 VF mutation as a critical molecular determinant of human myeloproliferative diseases and more recently described novel mutations in the thrombopoietin receptor that might be essential for hematological malignancies.
Constantinescu has published significant papers in the field of cytokine receptor traffic, dimerization, structure and function, on the role of transmembrane sequences in protein oligomerization and has received his postdoctoral training with prof. Popa Liviu M.