Endometrial cancer histological types. Particularităţile morfologice şi ultrasonografice ale pacientelor afectate de cancerul endometrial

Clinical , histopathological and immunohistochemical study of endometrial carcinomas

Several previous studies plasturi medicinali detoxifiere identified an association between endometriosis and the development of ovarian carcinomas.

This study aims to follow-up the prevalence of endometriosis and the histological features in ovarian tumors. Materials and method. The study group included 50 endometrial cancer histological types from the County Emergency Hospital of Galaţi diagnosed with different histological types of ovarian tumors of the surface epithelium during the period The cases were reviewed in order to highlight the presence of endometriosis and the different histopathological changes.

The average age of patients in the group with endometriosis associated with ovarian tumors was From the seven cases of tumors associated with endometriosis, two presented areas with atypia, considered premalignant lesions. Based on data obtained, we can conclude that endometriosis with atypia can be a precursor to the occurrence of type I ovarian carcinomas.

Keywords endometriosis, ovarian cancer, atypical endometriosis, premalignant lesion Rezumat Endometrial cancer histological types.

Why Is This Tool Useful?

Mai multe studii anterioare au identificat o asociere între endometrioză şi dezvoltarea carcinoamelor ovariene. Acest studiu urmăreşte prevalenţa endometriozei şi caracteristicile histologice în tumorile ovariene. Materiale şi metodă. În lotul de studiu au fost incluse 50 de paciente diagnosticate cu diferite tipuri histologice de tumori ovariene ale epiteliului de suprafaţă în perioada la Spitalul Judeţean de Urgenţă din Galaţi. Cazurile au fost reanalizate în vederea evidenţierii prezenţei endometriozei, precum şi a diferitelor modificări histopatologice ale acestora.

Vârsta medie a pacientelor a fost 59,4±11,35 ani în lotul pacientelor care au prezentat endometrioză asociată şi 59,5±13,4 ani în lotul pacientelor care au prezentat doar tumori ovariene. Din cele şapte cazuri de endometrioză, în două cazuri au fost evidenţiate zone cu atipii, considerate leziuni endometrial cancer histological types.

Identificarea endometriozei cu atipii la cele două cazuri — unul diagnosticat cu carcinom cu celule clare, iar celălalt cu carcinom endometrial, ambele incluse în tipul I de cancer ovarian — demonstrează faptul că endometrioza cu atipii poate fi un precursor în apariţia carcinoamelor ovariene de tip I.

Endometriosis is a gynecological condition, being characterized from a endometrial cancer histological types point of view endometrial cancer histological types the presence of glandular structures at the level of the endometrium and stroma in ectopic locations, such as ovary, pelvis, bladder, Fallopian tube, ovary representing the most common location 4,5.

The literature comprises multiple studies highlighting the link ciuperci garnitura the presence of endometriosis and its malignant transformation in the ovary, although other studies have not identified associations between these two 6,7.

It is estimated that the risk of malignant transformation of endometriosis is comprised between 0. Endometriosis with atypia is described as a preneoplastic lesion and is considered an intermediate pathway for the development of ovarian carcinoma 3. InSampson described for the first time the implications of endometriosis in neoplastic lesions by establishing several important criteria: the presence of endometriosis and the tumor in the same ovary, a similar histological pattern, the exclusion of the presence endometrial cancer histological types tumor metastasis from other locations 8.

InScott added one more criterion: highlighting the continuity between the benign endometrial cancer histological types the malignant epithelium 9. Atypia from endometriosis was proposed as endometrial cancer histological types preneoplastic lesion between endometriosis and ovarian cancer, as it refers to two major histological changes: cytological atypia and architectural atypia known as hyperplasia Cytological atypia is highlighted in the epithelium of an endometrial cyst, while the hyperplasia resembles to the hyperplasia present in the endometrium simple or complex with or without atypia Materials and method The study comprises patients of the Emergency County Hospital of Galaţi diagnosed with ovarian carcinoma during the period January — December The histopathological results were analyzed retrospectively endometrial cancer histological types identify the presence of endometriosis.

A number of diagnosed cases and ovarian endometrial cancer histological types were analyzed in order to identify the presence or absence of endometriosis, as well as the relationship between these two, based on the criteria listed before. In this study, we included and evaluated a number of 50 patients diagnosed with epithelial ovarian carcinomas, endometrial cancer histological types also with borderline ovarian tumors.

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The present study aims to identify the presence of endometriosis outbreaks with or without cytological or architectural atypia hyperplasia. Each case was evaluated from a histopathological point of view.

The number of paraffin blocks varied depending on the surgical pieces, being between 4 and 12 blocks, the slides resulting from the section of these blocks being processed and colored using the classic hematoxylin and eosin coloration.

Studiu clinico-patologic al tumorilor ovariene - experienţa de un an într-un centru medical

The following clinical and pathological data of the patients were taken into account: age, menopausal status, tumor histological type, tumor grading at the time of ovarian diagnosis.

The staging was made retrospectively according endometrial cancer histological types the system of the International Federation of Gynecology and Obstetrics FIGO after cases have been analyzed. The histological classification of ovarian carcinomas was based on the classification WHO of ovarian tumors. Results The histopathological evaluation performed on the group of 50 patients during the period has the following results: 45 cases were diagnosed with malignant tumors, 5 cases being borderline tumors.

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From the seven patients with endometriosis, None of the cases of borderline mucinous tumors, mucinous carcinoma, and undifferentiated carcinoma presented associated endometriosis outbreaks Table 1. Table 1.

  • Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale
  • Particularităţile morfologice şi ultrasonografice ale pacientelor afectate de cancerul endometrial
  • Uterine (Endometrial) Cancer: Prediction Tools | Memorial Sloan Kettering Cancer Center
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The presence of endometriosis in the appendages was Two of the seven cases in which the areas of endometriosis were visualized presented also endometriosis with atypia one case of complex hyperplasia, and the other with cytological atypia in the wall of an endometrial cyst. In our study, the average age at the moment of diagnosis was One of the studies reported in the literature identified an average endometrial cancer histological types of The association between endometriosis and ovar­ian cancer is reported in the expert studies under two categories.

In all other cases, the ovarian tumor literally coexisted with endometriosis without the identification of a transition 13, Ogawa et al.

endometrial cancer histological types

In this study, the transition between endometriosis and ovarian carcinoma was present only in two cases, representing Endometrial cancer histological types to the classification proposed by Kurman and Shih, all identified ovarian tumors were classified into two large groups: type I and type II. Type I contains low-grade serous carcinoma, endometrioid carcinomas, clear cell carcinomas, mucinous carcinomas, and transitional type carcinomas, while in type II the ovarian tumors are comprising high-grade serous carcinoma, mixed malignancies and undifferentiated carcinomas Most studies on this topic show that the prevalence of endometriosis is higher in the case of endometrioid carcinomas and especially those with clear cells compared to the mucinous and serous carcinomas 2,5,12, Another endometrial cancer histological types showed that This study comprises also an evaluation of the presence or absence of endometriosis in patients with ovarian tumors and the transition between endometriosis outbreaks and ovarian tumors.

According to endometrial cancer histological types study by Van Gorp et al. Category A consists of cases with areas of endometriosis present in the same ovary, with areas of histological transition between endometriosis and ovarian tumor.

Category B contains endometrial cancer histological types with outbreaks of endometri­osis without transition between endometriosis and tumor, while category C contains cases with endometriosis present in any endometrial cancer histological types location, for example in the pelvis, the contralateral ovary in extragonadal endometriosis 5.

In our study, from the seven cases of carcinomas presenting endometriosis outbreaks associated, in two cases there were highlighted areas of transition between the benign and the malignant process identified by the criteria listed by Sampson and Scott, and included in category A. From the five cases, the remaining four were classified in category B, and one case in category C.

Studiu clinico-patologic al tumorilor ovariene - experienţa de un an într-un centru medical

The presence of areas of endometriosis with atypia was made based on criteria which included the increase in volume or hyperchromatic of nuclei, or contrary, hypochromic nuclei, eosinophilic endometrial cancer histological types, branching and agglomeration or stratification, all according to the criteria suggested by LaGrenada and Silverberg The study is limited due to the low number of cases for some of the histological types.

Conclusions Endometrioid and clear cell carcinoma are the most common types of tumors in association with endometriosis included in type I tumors, according to the classification proposed by Endometrial cancer histological types and Shih. In this study, we encountered two cases of atypical endometriosis, a case of clear cell carcinoma, and one case of endometrioid carcinoma. In both cases, we observed the transition from a preneoplastic lesion to the neoplastic lesion, which makes us think that endometriotic atypia can be considered a precursor endometrial cancer histological types type I carcinomas.

[Myometrial invasion as a prognostic factor in endometrial adenocarcinoma].

Conflict of interests: The authors declare no conflict of interests. The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.

Endometrial cancer histological types Steril. Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis. Am J Obstet Gynecol. Munksgaard PS, Blaakaer J.

Он надеялся, что нужды в новом конфликте не возникнет, да и подготовлен он был теперь куда Взглянув на лица членов Совета, Элвин мгновенно понял, какое именно решение они приняли.

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skin cancer genetic predisposition

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Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale

Hum Pathol. Clement PB. The pathology of endometriosis: a survey of the many faces of a common disease emphasizing diagnostic pitfalls and unusual and newly appreciated aspects. Adv Anat Pathol. Prevalence of endometriosis in malignant epithelial ovary tumours.

The aim of this study is a retrospective analysis of the spectrum of ovarian tumors: statistics, epidemiology and pathological features, based on one-year experience in our hospital. Materials and method. We analyzed 58 cases registered in the Pathology Department as oophorectomy or hysterectomy specimens diagnosed with ovarian tumors, including benign, borderline and malignant tumors of various histological types. Based on their tumoral behavior, we had: three cases of benign tumors, all of them associated with a different histological tumor type and grade in the contralateral ovary, 12 cases of borderline tumors and 46 cases of malignant tumors 39 cases of endometrial cancer histological types and 7 cases of secondary tumors.

Garry R. Is insulin resistance an essential component of PCOS? The endometriosis syndromes: a clinical classification in the presence of aetiological confusion and therapeutic anarchy.

Histopathology Uterus--Endometrial adenocarcinoma

Hum Reprod. Endometriosis: a high-risk population for major chronic diseases? Hum Reprod Update. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol.

Clinical , histopathological and immunohistochemical study of endometrial carcinomas

Clinicopathological characteristics of ovarian carcinomas associated with endometriosis. Terada T.

endometrial cancer histological types

Endometrioid adenocarcinoma of the ovary arising in atypical endometriosis. Int J Clin Exp Pathol.

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