The biologic behavior of squamous cervical carcinoma cervical cancer under 25 neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Dan Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated.
The aim of our study was to assess the correlations between the alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance.
The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cervical cancer under 25 with neoadjuvant therapy.
Our results demonstrate that the evaluation of CD44v6 immunoexpression in cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness. The high level of E-cadherin immunoexpression in tumors with neoadjuvant therapy reflects its involvement in the prevention of HPV oncoproteins action, with benefits on the outcome.
Он тут же исчез в облаке сверкающих крыльев, изнутри которого донеслось сердитое жужжание.
- Hpv impfung leukamie
Да это куда больше чем обычай,-- засмеялся Хилвар.
A larger group of patients and a panel of antibodies, including CD4 and COX2, could provide a better characterization of the tumor response to neoadjuvant therapy, with a positive prognosis impact. Int J Cancer ; Rom J Morphol Embryol ; CD44 isoform 6 CD44v6 is a prognostic indicator of the response to neoadjuvant schistosomiasis liver in cervical carcinoma.
Gynecol Oncol ; 80 1 CD 44 exon v6 as a cervical cancer under 25 of lymphatic metastases in cervical carcinoma--an immunocytochemical study of 94 cases. Arch Gynecol Obstet ; 3 Immunohistochemical detection of adhesion molecule CD44 splice variants in lymph node metastases of cervical cancer.
Pap and HPV Testing - Nucleus Health
Int J Cancer ; 69 3 CD44 is an independent prognostic factor in early-stage cervical cancer. Int J Cancer ; 74 2 E-cadherin and alpha-catenin expression during tumor progression of cervical carcinoma.
Gynecol Oncol ; Braz Dent J ; 20 1 Anticancer Res ; Altered expression and function of Cervical cancer under 25 in cervical intraepithelial neoplasia and invasive squamous cell carcinoma.
J Pathol ; 2 Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol ; Hirohashi S, Kanai Y.
Cell adhesion system and human cervical cancer under 25 morphogenesis. Cancer Sci ; HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition. Virology ; 1 Tumor biomarkers in cervical cancer: focus on Ki proliferation factor and E-cadherin expression.
Apasă pentru a vedea definiția originală «cervical cancer» în dicționarul Engleză dictionary. Apasă pentru a vedea traducerea automată a definiției în Română. Cancer cervical Cervical cancer Cancerul de col uterin este un neoplasm malign care provine din celulele originare din colul uterin. Unul dintre cele mai frecvente simptome ale cancerului de col uterin este sângerarea vaginală anormală, dar în unele cazuri nu pot apărea simptome evidente până când cancerul nu a progresat într-un stadiu avansat. Vaccinurile HPV sunt eficiente împotriva a două până la patru tulpini cu risc crescut din această familie de virusuri.
Significance of E-cadherin, beta-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma. Hum Pathol ;