Material and methods: The gastric cancer diffuse type included surgical specimens from 40 patients with gastric carcinoma.
Histological sections were stained using current techniques: haematoxylin-eosin, trichromic van Gieson, and Alcian blue. Laurén histological classification with two main types of gastric carcinoma: gastric cancer diffuse type and diffuse was used to classify the specimens.
We assessed the proliferative activity by determining the percentage of immunoreactive cells for Ki67 antigen AM antibody Biogenex and comparing the Ki67 index with histological type. Results: Immunoreactivity was positive for ki in all cases: 12 cases of gastric carcinoma intestinal type — low to moderate index, 26 cases of gastric carcinoma diffuse type — moderate to high index and 2 cases of mixed gastric carcinomas — low to moderate index.
Conclusions: The positive rates for Ki67 along with histologic differentiation give us useful information regarding the evolution and the prognosis of gastric cancer. These observations prove that a high proliferative activity is a prognostic factor for a highly malignant phenotype of the tumor.
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