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Расселина все время увеличивалась и вскоре сделалась такой широкой, что через нее нельзя было перешагнуть. Еще секунда - и они оказались у начала расселины. Поверхность арены была продавлена и расколота так, что образовалась громадная пологая вмятина длиной свыше километра. Не требовалось особого разума и воображения, чтобы понять ее происхождение.

Department of Ophthalmology, Grigore T. E-mail: moc.

Metodele de testare pentru HPV cunoscute pina in prezent prezinta dezavantaje care nu trebuie neglijate: detecteaza un numar relativ mic de tipuri de HPV comparativ cu cele existente 37 de tipuri, fata de cele peste de tipuri cunoscutese aplica doar pentru prelevate cervicale in mediu lichid excluzind astfel leziunile anale, oro-faringiene, conjunctivale, epidermice, laringealeau sensibilitate limitata pentru unele tipuri, limita de detectie ajunge si la de copii ADN, ceea ce sugereaza un numar relativ mare de hpv virus not 16 18 fals negative, datorate fie recoltarii unui numar mic de celule, fie infectarii cu virus a unui numar mic de celule. Laboratoarele synlab utilizeaza acum o metoda de testare a HPV care exclude toate aceste inconveniente.

We report the detection of HPV 52 in a sample taken from a year-old patient with squamous cell carcinoma of the conjunctiva of the left eye. The method used for the detection of HPV was real time polymerase chain reaction.

The evolution was favorable after surgical removal of the tumor and the patient was explained that long-term follow-up is essential to avoid recurrence. Keywords: Conjunctiva, eye, human papillomavirus 52, real time polymerase chain reaction, squamous cell carcinoma Human papillomavirus HPV infection is strongly associated with anogenital tumors cervix, penis, vulva, vagina, anushead and hpv virus not 16 18 ectasia ductal papilloma oral cavity, esophagus, larynxand nonmelanoma skin cancers squamous and basal cell hpv virus not 16 18.

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The association between HPV infection and eye tumors is little explored territory. Di Girolamo brings forward a two-hit theory that explains cancerogenesis in OSSN: The first hit is mediated by ultraviolet radiation exposure that causes genetic alteration and the second hit is mediated by HPV infection in the susceptible cells.

Case Report We present a unique case of squamous cell carcinoma of the conjunctiva examined and treated in June The year-old patient presented at the Ophthalmology Department for mild stinging sensation and redness in the left eye for almost 1-year and a half. He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist.

The patient admits being a heavy smoker for almost 30 years and that in his free time he practices agriculture without using sunglasses.

All other ophthalmological findings were normal.

The changing epidemiology of HPV and cervical cancer

Conjunctival culture was performed before surgery, and no bacterial infection was found. The CT scan of the head and neck showed no signs of tumor invasion of the orbit or the lymph nodes.

The limbic lesion was removed surgically hpv virus not 16 18 2 mm margin of normal tissue and diathermy of the adjacent sclera was done. At the end, the remaining temporal defect was restored using a supero-nasal conjunctiva graft fixed in position with interrupted and surjet The excised tumor was cut into 2 fragments: One for pathology preserved in formalin and one for HPV genotyping preserved in Cobas polymerase chain reaction PCR solution and refrigerated at 4°C until processing.

Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma of the conjunctiva without koilocytosis [Figs.