The biologic behavior of squamous cancer cervical stages carcinoma after neoadjuvant therapy NAT according to immunohistochemical expression of E-cadherin and CD44v6 Mihaela Madalina Gavrilescu, Raluca Balan, Viorel Scripcariu, Cancer cervical stages Ferariu, Ludmila Lozneanu, Diana Popovici, Cornelia Amalinei Abstract The efficiency of neoadjuvant therapy in cervical carcinoma has been well demonstrated, although the cellular mechanisms of different response to this treatment have not been thoroughly investigated.
The aim of our study was to assess the correlations between cancer cervical stages alterations in E-cadherin and CD44v6 immunoexpression in cervical carcinoma, as a tool of evaluation the response to neoadjuvant therapy and its prognostic significance.
Treatments for Cervical Cancer
The intensity of CD44v6 immunoexpression was higher in more aggressive tumors and E-cadherin immunoexpression was approximately constant among the cases with neoadjuvant therapy. Our results demonstrate that the evaluation of CD44v6 immunoexpression in cervical carcinomas is useful for the assessment of tumor response to neoadjuvant therapy and of tumor aggressiveness.
The high level of E-cadherin immunoexpression in tumors with neoadjuvant therapy reflects its involvement in the prevention of HPV oncoproteins action, with benefits on the cancer cervical stages.
A larger group of patients and a panel of antibodies, including CD4 and COX2, could provide a better characterization of the tumor response to neoadjuvant therapy, with a positive prognosis impact. Int J Cancer ; Rom J Morphol Embryol ; CD44 isoform 6 CD44v6 is cancer cervical stages prognostic indicator of the response to neoadjuvant chemotherapy in cervical carcinoma.
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Gynecol Oncol ; 80 1 CD 44 exon v6 as a predictor of lymphatic metastases in cervical carcinoma--an immunocytochemical study of 94 cancer cervical stages. Arch Gynecol Obstet ; 3 Immunohistochemical detection of adhesion molecule CD44 splice variants in lymph node metastases of cervical cancer.
Int J Cancer ; 69 3 CD44 is an independent prognostic factor in early-stage cervical cancer. Int J Warts pregnancy symptom ; 74 2 E-cadherin and alpha-catenin expression during tumor progression of cervical carcinoma.
Gynecol Oncol ; Braz Dent J ; 20 1 Anticancer Res ; Altered expression and function of E-cadherin in cervical intraepithelial neoplasia and invasive squamous cell carcinoma. J Pathol ; 2 Complex networks orchestrate epithelial-mesenchymal transitions.
Cauza cancerului de col uterin este de papilomavirus uman HPV. Cancer cervical stages, early stages of cervical cancer typically cause no symptoms. Mai multe, cancerul cervical timpuriu nu are simptome. The contribution of immunohistochemical examination in diagnosis of cervical cancer - Ileana Barbu, Ştefania Crăiţoiu Contribuţia examenului imunohistochimic în diagnosticul cancerului de col uterin - Ileana Barbu, Ştefania Crăiţoiu Almost every case of cervical cancer could be prevented by effective cervical screening programmes together with vaccination against the Human Papilloma Virus HPV. Aproape cancer cervical stages caz de cancer al colului uterin ar putea fi prevenit prin programe eficace de screening si vaccinare impotriva Virusului Papiloma Uman HPV.
Nat Rev Mol Cancer cervical stages Biol ; Hirohashi S, Kanai Y. Cell adhesion system and human cancer morphogenesis. Cancer Sci ; HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transition.
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Virology ; 1 Tumor biomarkers in cervical cancer: focus on Ki proliferation factor and E-cadherin expression. Significance of E-cadherin, beta-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma.
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