Neuroendocrine cancer drugs

One of the major tools to evaluate this type of pathology neuroendocrine cancer drugs the neuroendocrine markers as chromogranin A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron specific enolase. They change related to the disease progression, regardless therapy. Some of the drugs that are used for NETs as neuroendocrine cancer drugs analogs for example octreotide might interfere with glucose metabolism. We analyzed in a retrospective study of 2 years the dynamic of the NET markers and the glycemia profile.

Material and Methods.

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All the patients had at least one assay per year. The dose of octreotide varied from 20 to 50 mg, monthly. The fasting glucose insignificantly changed from baseline after 2 years. No new case of diabetes was registered.

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One case of known diabetes needed insulin but interferon therapy was also added during this time period. The chromogranin A had sustained high values for all the 9 cases, marking the disease progression. The neuron specific enolase significantly neuroendocrine cancer drugs, and the serum serotonin as well as the 5HIIA was much higher in 2 cases with aggressive carcinoid symptoms. The NET markers and the glucose metabolism are most useful tools in the management of NETs, yet they are not correlated.

Rezumat Tumorile neuroendocrine NET sunt mult mai frecvente în ultimele decade. Unul din intrumentele majore de evaluare în această patologie este reprezentat de dozarea markerilor neuroendocrini precum cromogranina A, serotonina, acidul 5-hidroxi indolacetic urinar şi enolaza neuronal specifică.

Aceştia se neuroendocrine cancer drugs cu progresia tumorală, indiferent de terapie.

neuroendocrine cancer drugs

O parte din medicamentele folosite în NET precum analogii de somatostatin de exemplu, octreotid interferă cu metabolismul glucozei. Am analizat într-un studiu retrospectiv de-a lungul a 2 ani dinamica markerilor NET şi profilul glicemic.

Material si metode. Toţi pacienţii au avut cel puţin o evaluare pe an. Doza de octreotid a variat de la 20 la neuroendocrine cancer drugs mg lunar. Glicemia s-a modificat nesemnificativ de la bază după 2 ani. Nu s-a înregistrat el papiloma humano ano un caz nou de diabet. O pacientă a necesitat insulină pentru diabetul preexistent dar între timp s-a adaugat şi terapie cu interferon Cromogranina A a avut valori mari sustinute pentru toate cele 9 cazuri, sugerând progresia bolii.

neuroendocrine cancer drugs

Enolaza neuronal specifică a crescut semnificativ iar serotonina serică şi 5HIIA au crescut considerabil în 2 cazuri cu simptome severe de sindrom carcinoid. Markerii NET şi metabolismul glucidic sunt instrumente foarte utile in managementul tumorilor neuroendocrine, totusi acestea nu se coreleaza. Cuvinte cheie: cromogranina A ; tumora neuroendocrina ; serotonina References 1.

Neuroendocrine tumors.

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  • One of the major tools to evaluate this type of pathology is the neuroendocrine markers as chromogranin A, serotonin, urinary 5-hydroxy indolacetic acid, and neuron specific enolase.
  • Dan G. Duda - DF/HCC
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Endocr Relat Cancer. DOI: Oberndorfer S. Karzinoide tumoren des dunndarms. Frank Z Pathol.

Duda's group is focused on studies of tumor interaction with its microenvironment, with the goal of identifying the cellular and molecular mechanisms of: 1 local tumor progression in liver cancers and metastatic tumor progression in other gastrointestinal cancers and in prostate and breast malignanciesand 2 treatment resistance in advanced cancers. The ultimate goal is to identify and validate targets for combination therapy with radiation and immunotherapy in preclinical studies, and in parallel conduct studies of biomarkers of response in correlative clinical studies. He has been invited to present his results at over local, national and international meetings, including Grand Rounds, Plenary Talks neuroendocrine cancer drugs Keynote Lectures.

Google Scholar 3. Carcinoid Tumors. Bellizzi AM. Assigning site of origin in metastatic neuroendocrine neoplasms: a clinically significant application of diagnosis immunohistochemistry.

Revista Romana de Medicina de Laborator

Adv Anat Pathol. Chromogranins A, B, C: widespread consitituents of secretory vesicles. Ann N Y Acad Sci.

  1. Впрочем, вспомнить удалось немногое: спустя столь огромное время никто не мог отличить истину от легенды.

Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic neuroendocrine cancer drugs evaluation in patients with neuroendocrine tumors. Regul Pept. The poor prognosis factors in G2 neuroendocrine tumor. Rom J Morphol Embryol.

Dan G. Duda

Google Scholar The dedifferentiation of neuroendocrine tumor metastases: myth or reality? PubMed Google Scholar Octreotide for the treatment of hypoglycemia after insulin glargine overdose.

neuroendocrine cancer drugs

J Emerg Med. Biochemical testing for neuroendocrine tumors. The neuroendocrine cancer drugs relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors. Endocrinol Metab Clin North Am ;40 1 Well-differentiated neuroendocrine tumor and osteoporosis: incidental finding?

Treatment of malignant midgut carcinoid tumours with a long-acting somatostatin analogue octreotide.

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