Hepatocellular cancer stem cell

Olga Soritau

Project Director: Prof.

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Surgical tumor resection and liver transplantation, remain the only curative modalities for HCC, hepatocellular cancer stem cell recurrence rate is still high. In light of the dismal clinical outcome of this neoplasm, the development of effective systems that can predict the likelihood of recurrence is much needed.

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Classically, two general models of carcinogenesis have been debated: the stochastic model and the hierarchical model. The hierarchical model or cancer stem cell CSC model, postulates that a single CSC gives rise to a hierarchic hepatocellular cancer stem cell containing varied downstream descendants, proliferates extensively, and initiates tumors at high frequency.

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The role of liver stem cells in HCC carcinogenesis has been illustrated experimentally. Our project will allow the identification of new diagnosis and prognosis markers for HCC, potentially adding novel markers to the molecular classifications.

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Impact, relevance, applications. The impact of the project will be assessed by: The clinical impact — prediction of early recurrence leading to more aggressive follow-up after surgical therapy; potential identification of new molecular markers for targeted therapy; selection of patients for LT that have a low risk for recurrence according to identified significant markers.

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The social impact — increase of the quality of life and survival of HCC patients; increase of the efficacy of treatment methods by their applicability in early stages; allow the best use of the scarce number of liver allografts available The economic impact — decrease of the costs of medical assistance by optimizing the diagnostic and therapeutic act.

Current anticancer drugs kill differentiated cancer cells and cause a reduction in tumour mass. However, the cancer often recurs after treatment and this can be attributed to the presence of CSCs.

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Current research is now looking into a new generation of anticancer drugs or therapies that will selectively and specifically destroy various populations of CSCs while leaving the normal stem cell population unharmed, to allow for the complete regeneration of normal tissue.

This is of even more importance in liver cirrhosis setting as are the majority of  HCC patients that undergo resection. Other potential application is the identification of a gene expression signature that could effectively predict early recurrence of HCC independent of microarray platforms and cohorts, and provide novel biological insights into the mechanisms of tumor recurrence in HBV and HCV related HCC.

Project Team: Project Director: Prof.

Gheorghe Liana Team Members: Prof. Irinel Popescu, Prof. Management pattern of hepatocellular hepatocellular cancer stem cell at two tertiary centers in Romania. Recurrent hepatitis c following hepatocellular cancer stem cell transplantation in the romanian transplant program — treatment and outcome.

Olga Soritau

Recipi ent IL28B gene polymorphism and sustained viral response in Romanian patients with recurrent hepatitis C following liver transplantation. Quantitative gene expression of liver progenitor cells specific genes in curatively treated hepatocellular carcinoma.

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Impact of cytolysis after hepatocellular cancer hepatocellular cancer stem cell cell chemoembolization for hepatocellular carcinoma — a single center experience. Which oligosaccharide to use for minimal hepatic encephalopathy in liver cirrhosis patients — oligofructose enriched-inulin or lactulose? J Hepatol ; 60 hepatocellular cancer stem cell : S1:S Risk factors for 3 months mortality following liver transplantation in Romanian Transplant Program.

Risk factors for death in cirrhotic patients with non-malignant portal vein thrombosis on the waiting list for liver transplantation. J Gastrointestin Liver Dis Liver stiffness measurement is influenced by type of autoimmune-related liver papilloma gyogyitasa. Both cholestasis and portal hypertension predicted by liver stiffness, but not by spleen stiffness. Improved overall mortality on the Romanian waiting list for liver transplantation.

Referințe bibliografice pe an

Predictors of short-term post-liver transplant mortality in the Romanian Transplant Program. S Iacob. Screening for hepatocellular carcinoma. Iasi

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