For endometrial cancer recurrence rates, hair loss, which is one of the major concerns for some endometrial cancer recurrence rates, such as a young lady with BM of breast cancer, is a less frequently encountered problem with SRS than WBRT as a result of the smaller irradiated field size and focalized dose distribution Figure 2. All the aforementioned advantages of SRS are provided by utilization of multiple convergent narrow beams to deliver high dose focal irradiation in a single fraction by using multiple cobalt sources, linear accelerators or cyclotrons 37, Similar with neurosurgery, SRS alone or in combination with WBRT has been exhibited to associate with prolonged overall survival, local control and also better neurologic status in these patients compared to WBRT alone 33, However, SRS differs from neurosurgery by offering a chance of ablative treatment to those patients who are not appropriate candidates for neurosurgery due to various reasons.
Albeit such an approach may be beneficial in a select group of patients, prerequisites for close monitorization with monthly or bimonthly magnetic resonance imaging MRI and risk for unavoidable repeat SRS procedures for newly emerging BM, both increasing the total cost of overall treatment, should be carefully considered Moreover, contrasted with SRS and WBRT combination, the risk for a plausibility of inferior survival outcomes with SRS alone in patients with controlled primary and no extracranial disease should be kept in mind, as it has been accentuated previously by various authors 41, Although local- and distant brain control rates were reported to be better with the addition of WBRT, this distinction did not translate into a notable survival advantage in any study.
Furthermore, in the study by Chang et al. It is unfortunate to point out that the results of these RCTs ought to be interpreted with caution because of their insufficient design to explicitly concentrate on survival endpoints, such as significant imbalances between the study groups with regards to the prognostic factors and hpv impfung schule of salvage WBRT in SRS alone cohorts 43, First meta-analysis was performed by Duan et al.
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In the second meta-analysis, Hasan et al. Thirdly, the meta-analysis by Soon et al. In the fourth and most recent meta-analysis, by Sahgal et al. Additionally omission of WBRT in this subgroup was not identified to relate with increased rates of distant brain relapses.
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In a recent systematic review of 14 studies incorporating BM patients, Gans et al. Therefore, although the concept of TC-SRS is relatively new, with its acceptable toxicity rates the results appear to be encouraging for irradiation of a limited area with ablative endometrial cancer recurrence rates of radiotherapy.
In a study by Pinkham et al. Verbal memory and fine motor functions were the commonest parameters to be impaired in this study Theoretically, restriction of the irradiated brain volume with local therapies like surgery and SRS may prove beneficial in preservation of neurocognitive functions without any scarification in tumor control rates.
Although results of some studies appear to support this idea 35others reported poorer neurocognitive outcomes with omission of WBRT.
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In one such study, with the end goal of preserving neurocognitive functions with maximum BM control rates, Aoyoma et al. Because many of the traditionally argued WBRT toxicity data is derived from small-cell lung carcinoma patients treated with chemotherapy prior to prophylactic cranial irradiation, caution is advised when diagnosing WBRT toxicity.
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Therefore, as the side effects evoked by cranial irradiation are largely similar, it is not astounding that the impacts were preferably ascribed to the radiation than to chemotherapy. This information is of foremost significance for radiation oncologists considering the way that almost all toxicities following therapeutic WBRT are almost constantly ascribed to cranial irradiation by the other oncologic disciplines.
Deteriorations in neurocognitive functions may also be already present before the initiation of WBRT. This issue has been addressed in two key studies by Meyers et al.
In the second study by Komaki et al. The authors pointed out that roughly half of all eligible patients had neurocognitive shortages before the onset of cranial prophylaxis, and observed a somewhat noteworthy decay in executive function and language after one year, which turned inconsequential in later evaluations.
VitalSource eBook access code and instructions will be provided within the print book. Provides a comprehensive guide to modern cancer treatment focusing on patient management Supports an integrated approach to patient care involving radiotherapy, chemotherapy, and surgery where appropriate Features supporting online content including clinical practice guidelines, epidemiology and outcome statistics, patient support resources, and more.
These two excellent studies strongly emphasize the paramount importance of implementation of neurocognitive function tests prior to WBRT in order to reflect the actual impact of therapeutic WBRT on neurocognitive domains.
Moreover, the negative endometrial cancer recurrence rates impact of progressive BM may further be ameliorated or even improved by WBRT in some patients groups with resultant enhancement in executive functions and fine motor co-ordination as neurologic deterioration is reported to directly relate with disease progression in the brain 51, Management of this regretful complication of cancer involves neurosurgery, WBRT, SRS, chemotherapy, and targeted agents individually or endometrial cancer recurrence rates any combination of them, regarding the prognostic factors.
Curr Probl Surg J Clin Oncol Cancer Oncologist Cancer Metastasis Rev J Cell Biochem Endometrial cancer recurrence rates L: An overview of radiotherapy trials for the treatment of brain metastases. Oncology Williston Park ; discussion, Radiother Oncol Sperduto PW, Kased N, Roberge D, et al: Summary report endometrial cancer recurrence rates the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases.
Abrahams JM, Torchia M, Putt M, et al: Risk factors affecting survival after brain metastases from non-small cell lung carcinoma: a follow-up study of 70 patients. J Neurosurg Chin Clin Oncol BMC Cancer Strahlenther Onkol Rades D, Dziggel L, Haatanen T, et al: Scoring systems to estimate intracerebral control and survival rates of patients irradiated for brain metastases.
Topkan E, Parlak C, Kotek A, et al: Impact of prophylactic cranial irradiation timing on brain relapse rates in patients with stage IIIB non-small-cell lung carcinoma treated with two different chemoradiotherapy regimens. Coia LR: The role of radiation therapy in the treatment of brain metastases. Cancer Res Biomater Artif Cells Immobilization Biotechnol Mehta MP, Rodrigus P, Terhaard CH, et al: Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases.
Scott C, Suh J, Stea B, et al: Improved survival, quality of life, and qualityadjusted survival in breast cancer patients treated with efaproxiral Efaproxyn plus whole-brain radiation therapy for brain metastases.
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Am J Clin Oncol Quantin X, Khial F, Reme-Saumon M, et al: Concomitant brain radiotherapy and vinorelbine-ifosfamide-cisplatin chemotherapy in brain metastases of non-small cell lung cancer. Lung Cancer Mornex F, Thomas L, Mohr P, et al: A prospective randomized multicentre phase III trial of fotemustine plus whole brain irradiation versus fotemustine alone in cerebral metastases of malignant melanoma.
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Lancet Fabi A, Felici A, Metro G, et al: Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center.
J Exp Clin Cancer Res Histology, multiplicity, surgery, and survival. Chang EL, Wefel JS, Hess KR, et al: Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol Shaw E, Scott C, Souhami L, et al: Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and endometrial cancer recurrence rates metastases: final report of RTOG protocol Aoyama H, Shirato H, Tago M, et al: Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial.
JAMA Kocher M, Soffietti R, Abacioglu U, et al: Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: results of the EORTC study.
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Komaki R, Meyers CA, Shin DM, et al: Evaluation of cognitive function in patients with limited small cell lung cancer prior to and shortly following prophylactic cranial irradiation.
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Oxidation provides energy for maintenance of cellular integrity and functions. In thoroughbred race horses, as in other species subjected to physical activity, there is a rise in the imbalance between free radical production and antioxidant agents which leads to oxidative stress.
This review focuses on the main diagnostic and treatment aspects concerning anal canal cancer. Anal cancer incidence has been increasing in the last years, probably due to the rise in the spread of sexually transmitted diseases, such as HPV and HIV infections. Although many risk factors have been associated to anal cancer HPV, HIV infection, immunocompromised status, tobacco smokinganal cancer biology is only partly understood.
Anal canal cancer should be distinguished from anal margin cancer, which is of endometrial cancer recurrence rates prognosis. Anal cancer diagnosis is usually delayed, due to its resemblance to benign perianal pathology that justifies the need for a better screening.
Anal canal carcinoma therapeutic management has witnessed a major shift in time from a radical surgical abdominoperineal resection to multimodal approach. Nowadays, the standard treatment of anal carcinoma is represented by radiochemotherapy that is an effective therapy although can associate an important toxicity.
Surgical treatment is reserved only endometrial cancer recurrence rates very small anal lesions and especially to residual disease or tumor recurrences after primary therapy, representing a salvage therapy abdominoperineal rectal amputation for these cases. Inguinal lymphadenectomy is only indicated for voluminous lymphadenopathy blocks and inguinal lymph node metastases appeared after radiochemotherapy.
Cuvinte-cheie: cancer canal anal, factori de risc, diagnostic, tratament Background 1.
Endometrial cancer-staging and management
Incidence Endometrial cancer recurrence rates canal cancer is a relatively rare tumor, representing approximately 1. It is approximately 20 to 30 endometrial cancer recurrence rates rarer than colon cancer, but its annual incidence is increasing, reaching up to cases, with a female predominance 2.
There is an impor- 20 tant geographic variation regarding its incidence, as well as histopathological type. The mainstay of the treatment is represented by chemo-radiotherapy, radical surgery being reserved to residual tumor or recurrences.
Histopathology Depending on the lining epithelium, anal canal is divided into three regions: n colorectal zone: located proximally and containg columnar epithelium; n transitional zone: spread endometrial cancer recurrence rates a distance that varies between 0 and 12 mm that contains a pseudostratified type of epithelium resembling the urothelial one. A transformation zone is unanimously accepted in uterine cancer.
This region of metaplasia is extremely susceptible to HPV action 4 ; n squamous zone: contains a non-keratinized epithelium, without hair follicles.