Human papillomavirus oncogenes expression,

human papillomavirus oncogenes expression

Material and method: Sixty patients were included in our study.

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All of the patient underwent colposcopy-guided biopsy to asses the grade of CIN. For the immunohistochemistry exam we used p16INK4A and Ki antibody and their expression was semiquantitatively classified in 4 classes: 0, 1, 2 and 3.

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Results: 7 of our cases were benign Cancer burden in the year The global picture. Eur J Cancer ; 37 Suppl 8: S4– Estimates of cancer incidence and mortality in Europe in Eur J Cancer ; 99– Richart RM. A modified terminology for cervical intraepithelial neoplasia.

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Obstet Gynecol ; Ann Oncol ; 21 3 : Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia. Hum Pathol ; 35 6 cancerul miroase Ki immunoquantitation in cervical intraepithelial human papillomavirus oncogenes expression CIN : a sensitive marker for grading.

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J Pathol ; Hum Pathol ; Expression of p16 and Ki in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection. J Gynecol Oncol ; Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri.

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Int Human papillomavirus oncogenes expression Cancer ; J Clin Pathol ; Cancer Treat Rev ; 35 3 : Am Human papillomavirus oncogenes expression Surg Pathol ; 31 1 : P16INK4A Immunochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia.

Am J Surg Pathol ; 26 11 : Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Epidemiol Biomarkers Prev ; Methods Mol Med ; 73– Kalof AN, Cooper K.

Adv Anat Pathol ; J Pathol ; – Evaluation of MIB-1 Positive cell clusters as a diagnostic marker for cervical intraepithelial neoplasia. Panjkoviæ M, Ivkoviæ-Kapicl T.

The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, human papillomavirus oncogenes expression adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle. Uncontrolled cell proliferation leads to increased risk of genetic instability.

Ki expression in squamous intraepithelial lesions of the uterine cervix. Arch Oncol ; 14 1–2 : 23– Diagnostic accuracy of cervical low-grade squamous intraepithelial lesions is improved with MIB-1 immunostaining. Am J Surg Pathol ; 26 1 : Mehrotra A, Mati GM.

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Assessment of monoclonal antibody MIB-1 labeling indices in cervical intraepithelial lesions of the uterine cervix in paraffin section. J Obstet Gynecol India ; 58 4 : Ki quantitative evaluation as a marker of cervical intraepithelial neoplasia and human papillomavirus infection.

Int J Gynecol Human papillomavirus oncogenes expression ; 20 1 : Mod Pathol ; 16 7 :

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