During the 6 months of therapy, 2 patients died — of non-cardiovascular reasons 3. Analysis of the safety and tolerability profile In the 6 months of therapy, 8 patients As far as the incidence of adverse reactions during the study are concerned, they were reported by the patients and recorded in the specific monitoring forms.
The most common aspects were taken into consideration: muscular, digestive and neuropsychical disorders. No serious adverse event occurred such as hepatitis or myositis and all the reactions resolved following discontinuation of the drug therapy.
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- Even when the clinical appearance of the lesions strongly suggests MF, a biopsy may not bring histologic proof in favor of this diagnosis.
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The frequency of adverse events was higher in subgroup B. Myalgia All digestive reactions were more frequent in subgroup B and less frequent in subgroup A. Comparative presentation of adverse effects in subgroups A and B. The study group consisted of patients with CAD and with numerous associated risk factors for vascular events, while the pharmacological intervention with lipid-lowering therapy was prescribed for their secondary prophylaxis.
The mean level of HDL cholesterol was Also, one may note the high level of seric CRP in all patients with high common carotid artery IMT among the studied population.
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Modulation of atherosclerotic plaque burden is a new treatment target papilloma root word meaning patients with CAD. This was in contrast to the low dose regimen that only prevented the progression of papilloma root word meaning disease. Recently, the benefit of high dose atorvastatin therapy in preventing the progression of atherosclerotic plaque in coronary arteries was explained by the favorable reduction of CRP rather than LDL cholesterol levels.
Comparatively, this target was not reached in patients treated with moderate doses of statins.
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The plasma lipid profile modified in a positive way in both cases, with proven superiority in patients from the group that underwent intensive therapy Our study, adjacently to other main studies on the classical therapeutic action of statins on the lipid metabolism and modulation of atherosclerosis, confirms that the high doses of statins exercise significantly higher anti-inflammatory effects against C-reactive protein, comparatively with the moderate dosage regimens, with complex and favorable therapeutic implications in cardiovascular patients.
Papilloma root word meaning therapeutic efficacy of statins is dosedependant, regarding both the main pharmacodynamic effect on the plasma lipid profile and the secondary actions in reducing the atherosclerotic process by modulation of the inflammatory biological marker — seric CRP - or of the paraclinic marker — the carotidian IMT.
All papilloma root word meaning three parameters can be tratamiento farmacologico de oxiuros en ninos modified mostly by intensive dosage regimens comparatively with the moderate dosage regimens in the patients with CAD and mixed dyslipidemia of pleiotropic etiology. At high doses of statin therapy, the extensive pharmacodynamic action is associated with an alteration of the tolerability profile in comparison with the moderate dosage regimen, and therefore it is required to rigorously follow-up the patient and the laboratory parametersafferent to the hepatic or renal deteriorations and any other side-effect occurring during the therapy.
The physician must adjust the therapeutic doses for each patient individually, taking into account the level of plasma lipid fractions and the possible presence of other chronic diseases, especially hepatic or renal disease.
The clinical study on the efficacy of statin treatment associated with the control of risk factors papilloma root word meaning atherosclerosis in Papilloma root word meaning patients with carotid atheromatosis reveals the efficacy of statins on the reduction of the atherosclerotic risk and subsequent complications, besides the pleiotropic effects reflected in the modulation of the endothelial function, coagulation and plaque stabilization. Intensive versus moderate lipid lowering with statins after acute coronary syndromes.
N Engl J Med papilloma root word meaning Intensive lipid lowering with atorvastatin in patients with stable coronary disease. Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial.
JAMA ; Statin therapy, LDL cholesterol, C-reactive protein, and coronary disease. C-reactive protein levels and outcomes after statin therapy.
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N Engl J Med ;B. Association of coronary disease with segment specific intimal-medical thickening of the extracranial carotid artery. Circulation ; The carotid papilloma root word meaning thickness as a marker of the presence of severe symptomatic coronary artery disease. Eur Heart J ; Carotid-artery intima and media thickness as risk factor for myocardial infarction and stroke in older adults.
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Intima-media thickness of the common carotid artery is the papilloma root word meaning predictor of angiographically proven coronary artery disease. Can J Cardiol ; Usefulness of carotid intimamedia thickness measurement and peripheral B-mode ultrasound scan in the clinical screening of patients with coronary artery disease.
Angiology ; Carotid atherosclerosis is correlated with extent and severity of coronary artery disease evaluated by myocardial perfusion scintigraphy. Association of increased carotid media thickness with the extent of coronary artery disease.
Heart ; Does carotid intima media thickness indicate coronary atherosclerosis? Curr Opin Cardiol ; The role of carotid arterial intima-media thickness in predicting clinical coronary events.
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Ann Intern Med ; Am J Epidemiol ; Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolemia ASAP : a prospective, randomized, doubleblind trial. Lancet Effects of lipid-lowering by simvastatin on human atherosclerosis lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging.