Ovarian cancer histological classification

ovarian cancer histological classification

Several previous studies have identified an association between endometriosis and the development of ovarian carcinomas.

This study aims to follow-up the prevalence of endometriosis and the histological features in ovarian tumors. Materials and method. The study group included 50 patients from the County Emergency Hospital of Galaţi diagnosed with different histological types of ovarian tumors of the surface epithelium during the period The cases were reviewed in order hpv cancer treatment highlight the presence of endometriosis and the different histopathological changes.

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The average ovarian cancer histological classification of patients in the group with endometriosis associated with ovarian tumors was From the seven cases of tumors associated with endometriosis, two presented areas with atypia, considered premalignant lesions.

Based on data obtained, we can conclude that endometriosis with atypia can be a precursor to the occurrence ovarian cancer histological classification type I ovarian carcinomas. Keywords endometriosis, ovarian cancer, atypical endometriosis, premalignant lesion Rezumat Introducere.

  1. Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian
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Mai multe studii anterioare ovarian cancer histological classification identificat o asociere între endometrioză şi dezvoltarea carcinoamelor ovariene. Acest studiu urmăreşte prevalenţa endometriozei şi caracteristicile histologice în tumorile ovariene. Materiale şi metodă. În lotul de studiu au fost incluse 50 de paciente diagnosticate cu diferite tipuri histologice de tumori ovariene ale epiteliului de suprafaţă în perioada la Spitalul Judeţean de Urgenţă din Galaţi.

Cazurile au fost reanalizate în vederea evidenţierii prezenţei endometriozei, precum şi a diferitelor modificări histopatologice ale acestora. Vârsta medie a pacientelor a fost 59,4±11,35 ani în lotul pacientelor care au prezentat endometrioză asociată şi 59,5±13,4 ani în lotul pacientelor care au prezentat doar tumori ovariene. Din cele şapte cazuri de endometrioză, în două cazuri au fost evidenţiate zone cu atipii, considerate leziuni premaligne. Identificarea endometriozei cu atipii la cele două cazuri — unul diagnosticat cu carcinom cu celule clare, iar celălalt cu carcinom endometrial, ambele incluse în tipul I de cancer ovarian — demonstrează faptul că endometrioza cu atipii poate fi un precursor în apariţia carcinoamelor ovariene de ovarian cancer histological classification I.

Endometriosis is a gynecological condition, being characterized from a histopathological point of ovarian cancer histological classification by the presence of glandular structures at the level of the endometrium and stroma in tratament pentru oxiuri la gravide locations, such as ovary, pelvis, bladder, Fallopian tube, ovary representing the most common what is human papillomavirus (hpv) symptoms 4,5.

Incidence of endometriosis and atypical endometriosis in epithelial ovarian tumors

The literature comprises multiple studies highlighting the link between the presence of endometriosis and its malignant transformation in the ovary, although other studies have not identified associations between these ovarian cancer histological classification 6,7.

It is estimated that the risk of malignant transformation of endometriosis is comprised between 0. Endometriosis with atypia is described as a preneoplastic lesion and is considered an intermediate pathway for the development of ovarian carcinoma 3. InSampson described for the first time the implications of endometriosis in neoplastic lesions by establishing several important criteria: the presence of endometriosis and the tumor in the same ovary, a similar histological pattern, the exclusion of the presence of tumor metastasis from other locations 8.

InScott added one ovarian cancer histological classification criterion: highlighting the continuity between the benign and the malignant epithelium 9. Atypia from endometriosis was proposed as a preneoplastic lesion between ovarian cancer histological classification and ovarian cancer, as it refers to two ovarian cancer histological classification histological changes: ovarian cancer histological classification atypia and architectural atypia known as hyperplasia Cytological atypia is highlighted in the epithelium of an endometrial cyst, while the hyperplasia resembles to the hyperplasia present in the endometrium simple or complex with or without atypia Materials and method The study comprises patients of the Emergency County Hospital of Galaţi diagnosed with ovarian carcinoma during the period January — December The histopathological results were analyzed retrospectively to identify the presence of endometriosis.

A number of diagnosed cases and ovarian tumors were analyzed in order to identify the presence or absence of endometriosis, as well as the relationship cancer mamar la 80 de ani these two, based on the criteria listed before.

In this study, we included and evaluated a ovarian cancer histological classification of 50 patients diagnosed with epithelial ovarian carcinomas, but also with borderline ovarian tumors.

The present study aims to identify the presence of endometriosis outbreaks with or without cytological or architectural atypia hyperplasia. Each case was evaluated from a histopathological point of view. The number of paraffin blocks varied depending on the surgical pieces, being between 4 and 12 blocks, the slides resulting from the section of these blocks being processed and colored using the classic hematoxylin and eosin coloration.

The following clinical and pathological data of the patients were taken into account: age, menopausal status, tumor histological type, tumor grading ovarian cancer histological classification the time of ovarian diagnosis.

Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale

The staging was made retrospectively according to the system of the International Federation of Gynecology and Obstetrics FIGO after cases have been analyzed. The histological classification of ovarian carcinomas was based on the classification WHO of ovarian tumors.

Results The histopathological evaluation performed on the group of 50 patients during the period has the following results: 45 cases were diagnosed with malignant tumors, 5 cases being borderline tumors.

Figure 1. Figure 2.

ovarian cancer histological classification hpv sintomi bruciore

From ovarian cancer histological classification seven patients with endometriosis, None of the cases of borderline mucinous tumors, mucinous carcinoma, and undifferentiated carcinoma presented associated endometriosis outbreaks Table 1.

Table 1. The presence of endometriosis in the appendages was Two of the seven cases in which the areas of endometriosis were visualized presented also endometriosis with atypia one case of complex hyperplasia, and the other with cytological atypia in the wall of an endometrial cyst.

In our study, the average age at the moment of diagnosis was One of the studies reported in the literature identified an ovarian cancer histological classification age of The association between endometriosis and ovar­ian cancer is reported in the expert studies under two categories. In all other cases, the ovarian tumor literally coexisted with endometriosis without the identification of a transition 13, Ogawa et al.

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In this study, the transition between endometriosis and ovarian carcinoma was present only in two cases, representing According to the classification proposed by Kurman and Shih, all identified ovarian tumors were classified into two large groups: type I and type II.

Type I contains low-grade serous carcinoma, endometrioid carcinomas, clear cell carcinomas, mucinous carcinomas, and transitional type carcinomas, while in type II the ovarian tumors are comprising high-grade serous carcinoma, mixed malignancies and undifferentiated carcinomas Most studies on this topic show that the prevalence of endometriosis is higher in the case of endometrioid carcinomas ovarian cancer histological classification especially those with clear cells compared to the mucinous and serous carcinomas 2,5,12, Another study showed that This study ovarian cancer histological ovarian cancer histological classification also an evaluation of the presence or absence of endometriosis in patients with ovarian tumors and the transition between endometriosis outbreaks and ovarian tumors.

According to a study by Van Gorp et al. Category A consists of cases with areas of endometriosis present in the same ovary, with areas of histological transition between endometriosis and ovarian tumor. Category B contains cases with outbreaks of endometri­osis without transition between endometriosis and tumor, while category C contains cases with endometriosis present in any other location, for example in the pelvis, the contralateral ovary in extragonadal endometriosis 5.

Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian

In our study, from the seven cases of carcinomas presenting endometriosis outbreaks associated, in two cases there were highlighted areas of transition between the benign and the malignant process identified by the criteria listed by Sampson and Scott, and included in category Ovarian cancer histological classification.

From the five cases, the remaining four were classified in category B, and one case in category C. The presence of areas of endometriosis with atypia was made based on criteria which included the increase in volume or hyperchromatic of nuclei, or contrary, hypochromic nuclei, eosinophilic cytoplasm, branching and agglomeration or stratification, all according to the criteria suggested by LaGrenada and Silverberg The study is limited due to the low number of cases for some of the histological types.

Conclusions Endometrioid and clear cell carcinoma are the most common types of tumors in association with endometriosis included in type I tumors, according to the classification proposed by Kurman and Shih.

The utility of immunohistochemistry in the diagnosis of ovarian carcinoma

In this study, we encountered two cases of atypical endometriosis, a case of clear cell carcinoma, and one case of endometrioid carcinoma. In both cases, we observed ovarian cancer histological classification transition from a preneoplastic lesion to the neoplastic lesion, which makes us think that endometriotic atypia can be considered a precursor to type I carcinomas.

Conflict of interests: The authors declare no conflict of interests. The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer. Fertil Steril.

Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale

Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis. Am J Obstet Gynecol. Munksgaard PS, Blaakaer J. The association between endometriosis and ovarian cancer: a review of histological, genetic and molecular alterations.

Gynecol Oncol.

Material and method: The study has included women diagnosed with ovarian cancer.

Endometriosis-associated ovarian cancer: a review of pathogenesis. Int J Mol Sci. Endometriosis and the development of malignant tumours of the pelvis. A review of literature. Kokcu A. Relationship between endometriosis and cancer from current perspective. Arch Gynecol Obstet.

The purpose of this paper is to quantify the in­ci­dence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective screening program, considering the paucisymptomatic na­ture of this pathology. The incidence of ovarian epithelial tumors varied across age groups, our study group including women aged between 34 and 64 years old. Knowing the age distribution plays an important role in the implementation of screening pro­grams. All cases presented with similar symptomatology: pelvic pain, abdominal distension and ascites.

Association between endometriosis and cancer: a comprehensive review and a critical analysis of clinical and epidemiological evidence. Histologic transformation of benign endometriosis to early epithelial ovarian cancer. Perspectives et implications cliniques.

Gynécologie Obstétrique Fertil. Ovarian tumors associated with atypical endometriosis. Hum Pathol.

Ovarian Cancer

Clement PB. The pathology of endometriosis: a survey of the many faces of a common disease emphasizing diagnostic pitfalls and unusual and newly appreciated aspects. Adv Anat Pathol.

ovarian cancer histological classification

Prevalence of endometriosis in malignant epithelial ovary tumours. Garry R. Is insulin resistance an essential component of PCOS? The endometriosis syndromes: a clinical classification in the presence of aetiological confusion and therapeutic anarchy.

Hum Reprod. Endometriosis: a high-risk population for major chronic diseases? Hum Reprod Update. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol. Clinicopathological characteristics of ovarian carcinomas ovarian cancer ovarian cancer histological classification classification with endometriosis.

Terada T. Endometrioid adenocarcinoma of the ovary arising in atypical endometriosis. Int J Clin Exp Pathol.

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