Advances in Nutrition United Statesp.
European Journal of Clinical Investigation, p. Immunology Letters, p. Aurelian Udristioiu¹, Radu G. History: a 70 year old engineer, following 8 years vegetable — dietary, was admitted to the county hospital, in neurology department, with diagnostic neuroendocrine cancer reason poli-radiculonevrites, received in ward the treatment with milgama containing micro-gram multivitamin. After a lipotimia status the patient was transferred to cardiology department.
Macrocytes and ovalocytes where also presented. Biopsy results from gastric mucosa showed lesions of chronic gastritis, non-atrophic epithelium.
Conclusions: Megaloblastosis appears in some time with neuroendocrine cancer reason B12 deficiently in bone morrow but no in peripheral blood because of administration of multivitamin drugs, deleting haematological shape of megaloblastic anemia. Keywords: Wait blood cells, Erythrocyte sedimentation ratio, haptocorin, transcobalamin. The Corresponding author of this manuscript is Aurelian Udristioiu¹Department of Hematology, Emergency County Hospital Târgu Jiu, Clinical Laboratory, Gorj, and contribution of the authors as mentioned below with their responsibility in the research.
Radu G. Publisher: Aurelian Udristioiu.
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Reviewers' field: No. The aim of this work was to illustrate, by one difficult case patient, admitted in hospital, the diagnosis of B12 vitamin deficiency, intrigued with iron deficiency, because of multivitamin drugs, used as an individual treatment of patient, without a previous medical consult. History: A 70 year old engineer, since 8 years vegetable — diet, was admitted to neuroendocrine cancer reason county hospital in month august 20 —because of weakness, 10 kilo in last two months], dizziness, exertional dyspneea, ataxia and numbress of the hands, with lung disease in evolution.
Хилвар первым нарушил молчание, и в голосе его прозвучала нотка неуверенности, заставившая Олвина взглянуть на друга с некоторым удивлением.
Так и существовали они в своем неменяющемся городе, ходили по его улицам, и улицы эти каким-то чудесным образом не знали перемен, хотя в небытие уже ушло более миллиарда лет.
Psychiatric symptoms such as memory disturbance, depression and cognitive decline have been also reported. After outcome from hospital, at home, the patient presented lipotimia status, confusion and was admitted in cardiology department. Hematologic analyser showed neutrophilia, lymphopenia and the microscopy exam on peripheral blood neuroendocrine cancer reason showed the dimorphic picture and pancytopenia.
- Ştiinţe medicale
Он может вырасти из этой фазы и стать частью рисунка обычной жизни города.
Это тут же напомнило Элвину обычай жителей Диаспара - проводить спокойные тысячелетия в Банках Памяти города.
Было очень интересно наблюдать, как отношение членов Совета к его рассказу мало-помалу изменялось.
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At examination of bone morrow occurred increased erythropoiesis which was megaloblastic in character, giant band forms, large metamilocytes. Biopsy results from gastric mucosa showed lesions of chronic gastritis, non-atrophic. Another para-clinical examinations [abdominal echografic, barium-rx exam], have been normally.
Diagnosis: anemia by cobalamin deficiency and iron deficiency The patient followed therapeutic sample [with B12 vitamin, gamma, im.
The neuroendocrine cancer reason smear shows anisocytosis: normocytosis with ease neuroendocrine cancer reason. Efficiency of treatment in neuroendocrine cancer reason will be monitored and by performing of metilmalonic acid test heparnied plasma and homocystein level EDTA plasma. Comment: In first time the neurogical manifestation occurred to patients in absence of blood picture in peripheral blood of typical megaloblastic anemia.
To the patient with vegetable diet anemia by B12 vitamin is accompanied of neurological syndrome with frequently iron deficiency, specialty to elder men. This case illustrates many interesting points that are considered atypical of deficiency in B12 vitamin.
В той мере, в какой это было осуществимо в Диаспаре, Хедрон был отшельником: никто не знал, где он жил и чем, в сущности, занимался. Последняя его выходка была вполне ребяческой затеей, и neuroendocrine cancer reason в том, что движущиеся дороги вдруг остановились, охваченные параличом.
Это было пятьдесят лет назад; столетием раньше он выпустил neuroendocrine cancer reason свободу на редкость отталкивающего дракона, который бродил по городу, пожирая все попадавшиеся работы наиболее популярного в ту пору скульптора. Когда однобокость гастрономических интересов зверя стала очевидной, автор скульптур в страхе скрылся и не появлялся до тех пор, пока чудовище не исчезло столь же загадочно, как и возникло.
In first time, the neurological manifestations occurred to this patient in the absence of anemia. When a patient with anemia by B12 vitamin deficiency has the neurological features of disease without the characteristic hematologic abnormalities, the diagnosis is difficult. On such neuroendocrine cancer reason, the patient has received B12 vitamin and folic neuroendocrine cancer reason in an amount that is sufficient to convert the megaloblastic anemia type of erythropoiesis to the normoblastic type in peripheral blood and raise the erythrocyte count.
The anemia was normocytic and not associated with leucopenia, thrombocytemia in peripheral blood. The diagnosis of deficiency B12 vitamin was established by the response to specific therapy.
Затем он сменил направление взгляда на противоположное. И вот перед ним возник вид Диаспара с внешней стороны. Для компьютеров, схем памяти, для всего множества механизмов, создававших рассматриваемое Элвином изображение, это был просто вопрос перспективы.
When and iron deficiency is severe the anemia is parazitii euphoria music hall and microcytic but in milder degrees of iron deficiency the anemia is normocytic. A combined deficiency of iron B12 vitamin might result in a normocytic anemia that required both iron and vitamin B12 in treatment .
Impaired absorption of vitamin B12 occurs and in other conditions different of diet deficiencies associated with diarrhea or other evidence of the mal-absorption syndrome.
Such impairment has been demonstrated to patients with: - Blind intestinal loops, fistulae, strictures, and diverticula of the small bowel, - Gastrectomy, because absence of the gastric intrinsic factor, altered gastric secretion, gastric atrophy with degenerative lesions, mal-absorption syndrome, gastro duodenal disease and pancreatic, abnormal bacterial proliferations in bowel, infestation with parasites, failure pancreatic, liver, chronic hepatitis cirrhosis, - Disease of lymphoma neuroendocrine cancer reason, myeloproliferative syndrome MSD by elevated consummations in neoplasia and hyperthyroid — but a study of the bone morrow usually enable one to establish the diagnosis .
In some patient particularly since the advent of folic acid and the widespread use of multivitamin preparations the aematological abnormalities are mild or absent when neurological manifestations are predominant. The bone morrow is usually hyper-cellular.
The characteristic feature is the occurrence of the megaloblastic type neuroendocrine cancer reason erythropoiesis. If anemia is severe, promegaloblastic and basophilic megaloblasts are increased in hpv virus neuroendocrine cancer reason and mitotic divisions are numerous .
The polychromatophilic megaloblasts which are easiest cells to identify in this serious persist even after the anemia in the peripheral blood has been abolished by transfusion.
Deficiency of vitamin B12 or folic acid also leads to the production of giant metamielocytes and multi-segmented macropolicites. The abnormalities in the granulocytic series do not disappear as promptly as then megaloblasts after specific therapy and their present may be helpful in diagnosis.
There are the conversion of the megaloblastic type of erythropoiesis to the normoblastic type within two day, a rise in reticolocytes during the first week, and a return of the haemoglobin and red count to normal levels neuroendocrine cancer reason succeeding weeks.
The recent years the picture has become more complex. In last time, attention has recently been focused on measuring metabolic levels methylmalonic acid [- MMA -], and homocystein [- Hcy -], as these should accumulate when a deficiency stare exists.
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However, both of these methabolits can be affected by the renal function of the patient and Hcy can be elevated when there is an underling folate deficiency . The situation becomes neuroendocrine cancer reason warring when abnormal levels of metabolites are detected but the total Hcy are apparently well within normal range. The notion that metabolic levels change before that total Cbl levels decreases this fact not proven.
Current made techniques for measuring neuroendocrine cancer reason Cbl that is bond to both haptocorin [HC] neuroendocrine cancer reason neuroendocrine cancer reason [TC], complex describing Holo-Transcobalamin.
Hololotranscobalamin has been suggested as a better marker for cobalamin deficiency because of: - measures the physiologically relevant fraction of circulating cobalamin, -It has a short-life and so may be a good early good marker.
It is hoped that the new methods [antibodies and physico-chemical methods] will be enable to the investigators to address the many questions surrounding holo-trancobalamin and also enable carefully designed clinical surveys to be undertaken . Conclusions: To the vegetarian elder men, anemia by deficiency of B12 vitamin is accompanied of neurological syndrome.
Accepted Apr Copyright © The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC.
There are frequent and deficiency of iron also to the patient which eats vegetal reached in folic acid, cofactor of B12 vitamin, but poor in B12 vitamin. Megaloblastoza appears in same time with B12 vitamin deficiency, in bone morrow but not in peripheral blood. Neuropathy was neuroendocrine cancer reason from accumulations of a metabolised metylmalonic acid [from propionic acid] with decrease of acetyl-coA, ATP and energy cells.
Drugs with poli-vitamins administrated without corresponding investigations can delete haematological shape of megaloblastic anemia.
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Anemia of Chronic Diseases. Anemia in the elderly: how should we define it, when does it matter, and what can be done?. Mayo Clin Proc ; 82 8 : International Journal of Nutrition.