Although not-fulfilling all "the Amsterdam offers a homogenous but apparently rigid frame, considering criteria" for eligibility in the HNPCC group, the patients current molecular genetics research.
Thus, more and more with colo-rectal cancer and positive family history showed patients that do not fulfil entirely those criteria and an morphoclinical features which suggested poor prognosis important number of patients with sporadic cancers are found compared to those with negative family history.
A comparative analysis of the morphoclinical Key words features in non-polyposis colorectal cancer under 50 cancer patients with Hereditary colo-rectal cancer - Amsterdam Criteria - positive family histories which fulfil entirely or partially prognosis "the Amsterdam criteria" versus the patients with sporadic non-polyposis colorectal cancers.
Patients and methods. We performed a retrospective a n a l y s i s on c o l o - r e c t a l c a n c e r p a t i e n t s o p e r a colorectal cancer under 50 e d consecutively by the same surgical team.
The patients were Rezumat allocated into two groups: group A - patients with colo Introducere. The cases respecte "criteriile Amsterdam" care asigură un cadru with familial polyposis and those with uncertain family history omogen dar aparent rigid în lumina noilor cercetări de were excluded. We analyzed comparatively the differences genetică moleculară. Astfel, la tot mai mulţi pacienţi care in sex, age, stage, tumour site, pathological colorectal cancer under 50.
A number of colo-rectal cancer patients Scopul cercetării.
Analiza comparativă a particularită underwent surgery between and their medical ţilor morfo-clinice la pacienţi cu cancere colo-rectale non- records were assessed retrospectively. The group A contained polipoase cu antecedente heredo-colaterale pozitive şi care 30 patients with colo-rectal cancer colorectal cancer under 50 positive family întrunesc parţial sau cancer renal cauze "criteriile Amsterdam" faţă de history and group B consisted of patients with colo pacienţii cu cancere colo-rectale non-polipoase sporadice.
We noted Material şi metodă. Au colorectal cancer under 50 analizate retrospectiv important differences between the two groups regarding age cazurile de cancere colo-rectale operate consecutiv de in group A we found significantly more patients aged under aceeaşi colorectal cancer under 50. Au fost Vol.
Screeningul cancerului colorectal: ce este nou în ?
Mircca Cazacu antecedente heredo-colaterale incerte. Grupul A a cuprins 30 colorectal cancer under 50 history were excluded. We analyzed comparatively pacienţi cu cancere colo-rectale şi antecedente heredo- the differences in sex, age, Dukes stage, tumour site, colaterale pozitive iar grupul B a cuprins de pacienţi pathological features.
Deosebiri importante au fost decelate între cele significant. Their medical colorectal cancer under 50 were multe cazuri cu structură histologică de carcinom difuz, analyzed retrospectively.
The group A consisted of 30 patients with positive family Concluzii. Deşi pacienţii noştri cu cancere colo-rectale history and group B contained patients with negative şi antecedente familiale pozitive nu întrunesc toate family history.
The analysis of the morpho-clinical elements "criteriile Amsterdam" pentru încadrarea în grupul CCENP showed: aceştia prezintă particularităţi morfo-clinice de gravitate 1.
Sex - we noted a relatively uniform distribution of the crescută faţă de pacienţii fără antecedente heredo-colaterale. Age - the median age was Staging - considering the distribution of the colorectal cancer under 50 in entirely "the Amsterdam criteria". The relationship with the "Amsterdam Criteria": there rectal cancer in order to detect the differences between was no patient in group A that fulfilled all "The Amsterdam patients with positive malignant family history and those Criteria": 5 patients fulfilled 1 criteria, 9 patients fulfilled 2 with no such history.
Discussions Material and methods The scientific approach of the hereditary colo-rectal We analyzed retrospectively cases of colo-rectal cancer cancers has changed very much after the discovery of tumor operated on by the same surgical team.
Based on recent epidemiological data showing an increase in CRC incidence around the age of 50 years old, the American Cancer Society made a qualified recommendation to lower the age for starting the screening from 50 to 45 years old for all average-risk individuals. According to the American Cancer Society, a qualified recommendation indicates clear evidence of benefits, but less certainty about the risk-benefits balance. Age is important, but so are several other factors, such as male colorectal cancer under 50, a relative with CRC, high BMI, the metabolic syndrome, cigarette smoking, diet, inflamatory bowel disease, and the use of certain medications. In this context, whether to begin the screening at 45 or 50 years old seems relatively unimportant when compared to using the individual patient risk for CRC, the most adequate attitude being a personalized recommendation for screening. The objective of screening is to reduce the Colorectal cancer under 50 incidence and mortality.
The patients were microsatellite instability. Hereditary non-polyposis colo-rectal cancer between dogma and reality There are certain conditions which need to be colorectal cancer under 50 We consider that by confronting this situation, we can in order to permit the allocation of a patient in the HNPCC apply one of the new clinical subdivisions of colorectal group conditions defined in as "The Amsterdam colorectal cancer under 50 which allows the allocation in one of the 5 groups: Criteria".
The presence of colo-rectal cancers pathologically 2 HNPCC suspect - the cases that do not comply with all confirmed in at least three members of the family, one of the standard criteria; them being a first degree relative to the others.
Screening for colorectal cancer: what’s new in 2019?
Colo-rectal colorectal cancer under 50 present at least in two successive comply with the standard criteria but have relatives suffering generations. At least one of the family members diagnosed when 4 juvenile types - cases that fulfil only one criteria and aged under Although none of gene mutation This aspect has important - the estimation of individual risk, currently done by helminths vs parasitic worm regarding the indication of genetic testing of means of genetic testing, with all its social and economical all family members and the eventual costs of screening consequences, evaluation of certain risk groups 5.
Thus we use on a Thus, taking as genetic criteria the presence of mismatch- large scale family history investigation and also laboratory repair-gene mutation, the situations which suggest the tests and we hope the future will bring us new techniques presence of a hereditary colorectal cancer are: such as the detection of human leucocyte antigens as genetic - the presence of colorectal cancer under 50 cancer in at least 3 family markers in colo-rectal carcinoma Among the paraziti tratament homeopat cases operated by us follow-up.
References Facing this diversity we compared the main morpho- 1. Vincent T.
DcVita Jr. The differences were Hereditary colorectal ; Gut ; Familial and hereditary factors in colorectal cancer: a new 4.
Baba S. Hereditary nonpolyposis colorectal cancer: an update.
Screeningul cancerului colorectal: ce este nou în 2019?
Dis Colon Rectum ; 40 10 Suppl : S Br J Cancer ; 73 Suppl 26 Hereditary nonpolyposis Genetics of colorectal cancer. Non-polyposis and polyposis criteria show extremely low frequency of mismatch-rcpair-gcnc forms of hereditary colorectal cancer.
Ned Tijdschr Gcnecskd mutations. Am J Hum Genet ; Family history Genetic testing in characteristics, tumor microsatcllitc instability and gcrmlinc hereditary colorectal cancer: indications and procedures. Gastroenterol ; Hum Genet ; Varying features of clinical consequences of predictive molecular testing.
Int J early agc-of-onsct "sporadic" and hereditary nonpolyposis colo- Colorectal Dis ; Dis Colon Rectum ; Human 8. Hereditary background of Dis Colon Rectum ; Ned Tijdschr Gcnecskd Related Papers.