We plan to further refine our current understanding of the molecular-level processes responsible in this disease in the framework of pancreatic cancer stages projects and with the help of a specialized molecular-biology lab by using various high-throughput technologies not just microarrays to dissect the pathways involved in PDAC and to test these on cell lines and possibly animal models.
Bioinformatic analysis of the lung cancer dataset of Bhattacharjee et al. We are therefore pancreatic cancer stages them in conjunction with literature analysis tools for - validating certain transcriptional influences, as well as - emphasizing the various signaling pathways in which these genes operate.
The partial results are very encouraging.
For example, for the squamous cell lung carcinoma we have found essentially two groups of differentially expressed genes: - a set of upregulated genes pancreatic cancer stages e. Apparently, this cancer subtype seems to be due to a defective re-enactment of normal developmental processes at a wrong time and place.
Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. Generalized Clustergrams for Overlapping Biclusters.
Studies in Informatics and Control, Vol. Bry, C.
What is Pancreatic Cancer: 10 Things You Should Know About Pancreatic Cancer - Cancer Research UK
Koch, T. Furche, S.
Schaffert, L. Badea, S. Towards a semantic web for bioinformatics.
Dis Markers ; Mineral bone disorders MBDs constitute a hallmark of CKD, and alongside cardiovascular complications, they underlie a poor prognosis for these patients. Thus, our study focused on novel CKD biomarker patterns and their impact on the clinical staging of the disease. As a first testing approach, pancreatic cancer stages relative expression levels of proteins were assessed by the Proteome Profiler Cytokine Array Kit for pooled CKD stage serum samples to establish an overall view regarding the proteins involved in CKD pathogenesis.