Chronic inflammation is involved in tumor development, tumor growth, progression and metastasis and, also, in resistance to therapy.
As it is already acknowledged inflammatory bowel diseases IBD such as ulcerative colitis and Crohn disease are closely linked to an increased risk of colorectal cancer as high as 10 fold. Various inflammatory cytokines have been studied as they facilitate the tumor development.
New or Recurrent Cancer in IBD Patients - IBD in the News
Among those the most relevant are: C reactive protein, interleukin 6 and tumor necrosis factor alpha. The majority of published studies points toward a positive link between the increased serum level of those inflammatory molecules and the risk of colorectal cancer.
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Future studies are needed to address the issue of novel oncological therapy that interfere with inflammatory mechanism of colorectal cancer. However, users may print, download, or email articles for individual use.
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